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. Author manuscript; available in PMC: 2016 Feb 13.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Jan 8;55(7):2550–2554. doi: 10.1002/anie.201510551

Figure 2.

Figure 2

(a) Effect of GLUT1 inhibitor EDG on the cellular uptake of 1–4 and cisplatin (10 μM compounds, 17 h). (b) Effect of externally added D-glucose and L-glucose (10 μM compounds, 17 h). (c) Effect of EDG on the IC50 values (72 h assay). (d) Effect of EDG, Ctd, and their mixture on the cellular up-take of 1, 4 and oxaliplatin (10 μM compounds, 8 h). All experiments were done in A2780 cells and cellular uptake in absence of inhibitor was normalized to 100%. Data represent the mean ± SD of at least three or more replicates. The asterisks denote differences are statistically significant (*p < 0.01, **p < 0.001), ns = not statistically significant.