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. Author manuscript; available in PMC: 2017 Jan 26.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Dec 17;55(5):1675–1679. doi: 10.1002/anie.201507728

Figure 4. A 2D contour diagram showing different states of Npm-N in alternative order-disorder transition pathways.

Figure 4

The purple arrows are guides to the eye for the direction of transition among different states under high salt/partner binding (folding-induced-assembly) and low salt (unfolding-induced-disassembly). The effect of phosphor-mutation in each step is shown by a relative activation energy barrier. Also shown is the effect of Arf in arresting Npm-N in ordered pentamer.