Table 1.

Study descriptions: sample sizes, G (minor) allele frequencies (overall, in general dependence cases, in general dependence controls), proportions of male participants, and age distribution (minimum, first quartile, median, third quartile, and maximum) of each study.

Study	Total N	G-allele- freq	Case G- allele- freq	Control G- allele- freq	proport- male	age min	age_q1	age_med	age_q3	age_max
BG a	3999	0.14	0.13	0.17	0.83	18	25	28	30	58
CADD b	409	0.13	0.12	0.18	0.56	12	21	28	47	72
CATS c	1748	0.12	0.12	0.13	0.57	18	29	36	43	65
CEDAR-SADS d	747	0.12	0.12	0.12	0.35	14	18	37	42	65
Cinciripini e	627	0.11	0.09	0.15	0.48	18	33	42	50	74
COGA f	1024	0.12	0.11	0.13	0.46	18	36	43	51	77
COGEND g	2024	0.13	0.13	0.15	0.61	25	32	37	41	65
Finnish Health 2000 h	1025	0.21	0.20	0.22	0.8	30	37	46	54	87
FSCD i	558	0.13	0.13	0.10	0.5	18	25	34	40	54
FT12 j	617	0.22			0.48	20	22	22	23	27
GADD k	281	0.12	0.13	0.15	0.57	12	15	16	19	61
GESGA l	3501	0.12	0.11	0.11	0.65	18	39	47	56	84
Kreek m	750	0.11	0.10	0.13	0.59	17	31	43	52	82
MCTFR-Parents n	3842	0.11	0.10	0.11	0.46	30	43	46	50	72
NAG-AUS o	1281	0.12	0.12	0.12	0.59	18	36	43	50	82
NAG-FIN p	879	0.21			0.7	42	52	55	58	77
NYS q	552	0.1	0.07	0.10	0.49	35	37	39	41	44
OYSUP r	357	0.13			0.5	20	21	21	21	23
PAGES s	409	0.11			0.68	17	27	37	45	68
PiP t	809	0.11	0.11	0.15	0.48	18	35	43	53	79
ROMA u	732	0.21	0.16	0.38	0.83	18	25	28	32	53
SMOFAM v	166	0.12	0.18	0.12	0.63	26	27	29	30	62
Utah w	463	0.13	0.12	0.14	0.59	25	54	61	67	86
VA-Twin x	672	0.12	0.15	0.10	0.32	21	30	38	46	58
Yale-Penn y	1217	0.12			0.41	16	30	39	46	72
Total	28689	(0.10–0.22)			(0.32–0.83)	(12–42)	(15–54)	(16–61)	(19–67)	(23–87)

References:

^a(Nikolov et al. 2011);

^b(Stallings et al. 2005; Stallings et al. 2003);

^c(Nelson et al. 2014; Nelson et al. 2013);

^d(Maher et al. 2011);

^e(Carter et al. 2008; Cinciripini et al. 2006; Cinciripini et al. 2005; Lam et al. 2012; Minnix et al. 2011; Robinson et al. 2007; Robinson et al. 2011);

^f(Edenberg 2002; Edenberg et al. 2010);

^g(Saccone et al. 2009a; Saccone et al. 2009b);

^h(Aromaa and Koskinen 2004; Rouvinen-Lagerstrom et al. 2013);

ⁱ(Bierut et al. 2010; Bierut et al. 2008);

^j(Broms et al. 2012; Kaprio et al. 2002);

^k(Kamens et al. 2013);

^l(Frank et al. 2012; Treutlein et al. 2009);

^m(Levran et al. 2008);

ⁿ(Iacono et al. 1999; Keyes et al. 2009; McGue et al. 2007; Miller et al. 2012);

^o(Loukola et al. 2008; Saccone et al. 2007);

^p(Loukola et al. 2008);

^q(Elliott et al. 1985; Elliott et al. 1989; Hoft et al. 2009);

^r(Andrews et al. 2003);

^s(Van den Oord et al. 2006);

^t(David et al. 2011);

^u(Nikolov et al. 2011);

^v(Hops et al. 2000);

^w(Weiss et al. 2008);

^x(Chen et al. 2009; Kendler et al. 2007; Zhang et al. 2006b);

^y(Gelernter et al. 2014; Gelernter et al. 2013a; Gelernter et al. 2013b)