Table 4.

Summary of the effect of rs1799971 on specific substance dependence diagnoses in 9 studies that assessed all five substance dependence diagnoses and exposures.

Ordinal Logistic Regression Results
Substance	Cases	Controls	Cochrane’s Q	Q-Pvalue	Odds Ratio	L95%-U95%	OR-Pvalue
Alcohol	2031	3361	8.90	0.351	0.90	0.76–1.06	0.218
Nicotine	2718	2674	7.78	0.455	0.89	0.74–1.07	0.216
Cannabis	839	4553	10.76	0.216	0.91	0.73–1.14	0.420
Cocaine	992	4085	0.86	0.990	0.92	0.69–1.24	0.593
Opioid	607	4274	3.12	0.682	0.91	0.65–1.27	0.577
Traditional Logistic Regression Results (Dependence as outcome variable)
Alcohol	2051	3430	10.66	0.222	0.88	0.76–1.02	0.974
Nicotine	2066	1412	8.69	0.276	0.91	0.76–1.08	0.267
Cannabis	861	3036	9.08	0.336	0.90	0.74–1.09	0.283
Cocaine	1011	899	0.85	0.997	0.91	0.70–1.19	0.492
Opioid	600	577	2.31	0.679	0.91	0.67–1.24	0.547

Substance column shows the tested outcome phenotype. All effects shows are fixed effect estimates. In the traditional logistic regression results, controls were required to be exposed each tested substance, in addition to meeting the previously applied filters for age and exposure to alcohol.