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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Psychopharmacology (Berl). 2015 Nov 27;233(5):761–771. doi: 10.1007/s00213-015-4154-0

Fig 4.

Fig 4

The effects of varenicline on the ketamine-related impairments in performance of a reversal learning task in middle-aged/aged pigtail monkeys. (A) Effects of different doses of varenicline or vehicle when combined with ketamine on accuracy. B) Effects of different doses of varenicline or vehicle when combined with ketamine on the number of perseverative errors. (C) Effects of different doses varenicline or vehicle when combined with ketamine on the number of regressive errors. In these studies, varenicline was administered orally 60 min before testing and ketamine was administered by i.m. injection 45 min before testing. Each bar represents the mean ± S.E.M. *p<0.05, **p<0.01, ***p<0.001 = significant difference from vehicle-related response. #p<0.05, ##p<0.01, ###p<0.001 = significant difference from the ketamine alone response. N=6.