Table 2.
Comparison of Optimal Doses of nAChR agonists on Matching Accuracy in Monkeys
| Drug
|
nAChR Activity
|
N
|
Task
|
Age
|
Delay
|
Average % Change from Baseline
|
|---|---|---|---|---|---|---|
| nicotine | nonselective agonist | 10 | DMTS | Adult | Long | 15.1 |
| ABT-418 | α4β2 agonist | 6 | DMTS | Aged | Long | 15.7 |
| ABT-089 | α4β2 partial agonist | 6 | DMTS | Aged | Long | 12.7 |
| ABT-594 | α4β2 agonist | 7 | DMTS | Adult | Long | 11.3 |
| A-582941 | α7 agonist | 7 | DMTS | Adult | Long | 22.0 |
| varenicline | α4β2 partial agonist | 8 | DMTS | Aged | Long | 13.6 |
| α7 full agonist | ||||||
| nicotine | nonselective agonist | 8 | DMTS-D | Adult | Short | 17.5 |
| ABT-418 | α4β2 agonist | 8 | DMTS-D | Adult | Short | 17.5 |
| ABT-089 | α4β2 partial agonist | 8 | DMTS-D | Adult | Short | 34.4 |
| ABT-594 | α4β2 agonist | 7 | DMTS-D | Adult | Short | 12.0 |
| varenicline | α4β2 partial agonist | 8 | DMTS-D | Adult | Short | 19.6 |
| α7 full agonist |
Abbreviations: nAChR, nicotinic acetylcholine receptor; DMTS, delayed match to sample; DMTS-D, delayed match to sample with distractors
Adult = 7–18 years old; aged = >19 years old