Figure 8. Proposed illustration of protein degradation pathways in lung cancer cells.

(a). Untreated cells utilize two intracellular catabolic pathways for the removal of misfolded proteins. (b). As CFZ blocks the ubiquitin proteasome system, resistant cells degrade misfolded proteins through increased use of the autophagy-lysosome pathway. (c). Blocking the two major degradation pathways with CFZ + SAHA treatment results in the accumulation of misfolded proteins, ER stress, and cell death.