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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Cancer Res Clin Oncol. 2015 Sep 18;142(3):549–560. doi: 10.1007/s00432-015-2047-6

Table 1.

Sensitivity of NSCLC cell lines to CFZ and SAHA.

Cell Line CFZ IC50 (nM) SAHA IC50 (nM) CFZ+SAHA IC50 (nM) Combination Index
48 h 72 h 48 h 72 h 48 h 72 h 48 h 72 h
H520 15.13 1.10 20251 8941 8.13 0.59 0.30 0.26
A549 127.3 104.8 6871 6340 11.38 17.89 0.19 0.29
H1993 12.94 5.36 8103 6827 6.66 4.40 0.35 0.68
H460 56.50 41.21 10448 7203 22.06 20.82 0.21 0.33
H1299 8.03 16.30 25609 24418 10.52 11.46 0.87 0.76

The determined inhibitory concentrations (IC50 values) represent the level of drug that inhibited cell growth by 50%. IC50 values (nM) are the mean of one experiment, n=6. Combination index (CI) values were obtained by the method described by Chou and Talalay (1983). Values shown are an average CI from a single experiment at growth inhibition rates of 50%, 75%, 90% and 95%. CI interpretation: <0.3 = strong synergism, 0.3-0.7 = synergism, 0.7-0.9 = moderate to slight synergism, 0.9-1.1 = nearly additive, 1.1-1.45 slight to moderate antagonism.