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. Author manuscript; available in PMC: 2017 Feb 11.
Published in final edited form as: Cell. 2016 Feb 4;164(4):681–694. doi: 10.1016/j.cell.2015.12.034

Figure 6. Gene expression signatures in tumors with high and low DCE signal.

Figure 6

(A) Unsupervised clustering of RNA-Seq data from tumor fragments. Data included quantitation of all detected transcripts (left) or a subset of transcripts from 2,756 genes involved in metabolism.

(B) Results of GSEA using transcripts from metabolic genes. The 20 most enriched gene sets are shown for the high and low DCE groups.

(C) GSEA plots for three gene sets enriched in low DCE tumors.

(D) Proposed model for utilization of alternative fuels in NSCLC tumors with regional differences in perfusion.