Table 4.
Predicting Mood with Thyroid Measures, Trauma, and Lifetime Depression History Together
| -----------------Thyroid Predictor---------------- | -----------------Trauma Predictor----------------- | ---Lifetime Major Depression Predictor--- | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Standardized | Non- Standardized |
Standardized | Non- Standardized |
Standardized | Non- Standardized |
|||||
| Mood Outcome | Thyroid Predictor |
Beta (SE) | Beta (SE) | P-value | Beta (SE) | Beta (SE) | P-value | Beta (SE) | Beta (SE) | P-value |
| EPDS | −0.10 (D.Q5) | −2.22 (1.17) | 0.061 | 0.23 (0.06) | 0.37 (0.09) | <.001 | 0.32 (0.11) | 1.48 (0.51) | 0.004 | |
| STAI | FTA (ng/L) |
−0.07 (0.06) | −3,18 (2.49) | 0.202 | 0.17(0.06) | 0.54 (0.19) | 0.005 | 0.30 (0.12) | 2.72 (1.10) | 0.014 |
| MADRS | −0.09 (0.05) | −3,10 (1.77) | 0.081 | 0.25 (0.05) | 0.61 (0.13) | <.001 | 0.39 (0.11) | 2.72(0.76) | <.001 | |
| HAMA | −0.12 (0.05) | −3.21 (1.37) | 0.020 | 0.24 (0.06) | 0.46 (0.11) | <.001 | 0.49 (0.11) | 2.65 (0.60) | <.001 | |
| Depression Diagnosis | −0.42 (0.23) | −1,97 (1.08) | 0.067 | 0.33(0.20) | 0.11 (0.07) | 0.101 | 0.50 (0.41) | 0.50 (0.41) | 0.228 | |
|
| ||||||||||
| EPDS | −0.10 (0.05) | −0.057 (0.030) | 0.059 | 0.24 (0.06) | 0.39 (0.09) | <.001 | 0.34 (0.11) | 1.55 (0.51) | 0.003 | |
| STAI | TDG (mg/L) |
−0.11 (0.06) | −0.123 (0.064) | 0.057 | 0.18 (0.06) | 0.58 (0.19) | 0.002 | 0.29 (0.12) | 2.66 (1.10) | 0.016 |
| MADRS | −0.10 (0.05) | −0.090 (0.044) | 0.043 | 0.26 (0.05) | 0.64 (0.13) | <.001 | 0.39 (0.11) | 2.72 (0.76) | <.001 | |
| HAMA | −0.10 (0.05) | −0.067 (0,035) | 0.061 | 0.26 (0.06) | 0.50 (0.10) | <.001 | 0.49 (0.11) | 2.69 (0.60) | <.0O1 | |
| Depression Diagnosis | −0.56 (0.20) | −0.069 (0.024) | 0.005 | 0.51 (0.21) | 0.18(0.07) | 0.016 | 0.65 (0.42) | 0.65(0.42) | 0.122 | |
Regression coefficients and p-values for EPDS, STAI, MADRS, and HAMA outcomes were computed from a repeated measures model measuring the outcome at 3 time points (late pregnancy, 6 weeks, and 12 weeks postpartum). Coefficients and p-values for the depression diagnosis outcome were computed from a univariate logistic regression model for the outcome of major or minor depression during the study period (yes/no). All models include the following predictors: baseline (pregnancy weeks 31-33) thyroid values (either FT4 or TBG), lifetime trauma, or lifetime major depression history, as well as significant covariates (e.g., age, race, sex hormone concentrations, etc.). Estimated regression coefficients for predictors in each model are displayed with their original scale (labeled “Non-standardized”) as well as from models fit where continuous outcomes, predictors, and covariates have been scaled to have mean zero and standard deviation one (labeled “Standardized”). Categorical outcomes, predictors, and covariates (e.g., depression diagnosis, lifetime major depression, race, etc.) were not standardized in any model. The standard deviations used for the standardization are as follows: FT4: 0.21; TBG: 8.12; Lifetime trauma: 2.85; EPDS: 4.57; STAI: 9.20; MADRS: 7.00; HAMA: 5.44.