Table III.
Proportional mean squared error of estimation for each parameter, from each model, with Npairs = 1000
Parameter | Normal | Lognormal | Ordinal | LGP | NegBin |
---|---|---|---|---|---|
Mean | 0.0026 | 0.0007 | -- | 0.0024 | 0.0024 |
Phenotypic Variance | 0.0267 | 0.0014 | -- | 0.0169 | 0.0683 |
MZ Covariance | 0.0624 | 0.0062 | -- | 0.0185 | 0.0710 |
DZ Covariance | 0.0936 | 0.0115 | -- | 0.0214 | 0.0707 |
MZ Correlation | 0.0220 | 0.0040 | 0.0025 | 0.0012 | 0.0012 |
DZ Correlation | 0.0441 | 0.0088 | 0.0128 | 0.0033 | 0.0032 |
Additive-Genetic Variance | 0.9931 | 0.1554 | -- | 0.0733 | 0.1071 |
Shared-Environmental Variance | 0.5316 | 0.0939 | -- | 0.0506 | 0.0831 |
Nonshared-Environmental Variance | 0.0868 | 0.0113 | -- | 0.0205 | 0.0670 |
Heritability | 0.9045 | 0.1548 | 0.1883 | 0.0577 | 0.0561 |
Shared-Environmentality | 0.4363 | 0.0903 | 0.1138 | 0.0305 | 0.0294 |
notes: Proportional mean squared error is the ratio of the mean squared error of the estimator to the square of the true parameter value. Table presents data from the simulation condition in which samples consisted of 1000 twin pairs. Because of constraints necessary to identify the ordinal model, some of its parameters are not freely estimated or are redundant with other parameters. Generalized estimating equations analyses were conducted for each parameter. The pMSE for the MZ correlation did not significantly differ between the negative binomial and LGP models, but all other pairwise comparisons were statistically significant (smallest χ2(1df) = 11.55).