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. Author manuscript; available in PMC: 2016 Feb 14.
Published in final edited form as: Biochim Biophys Acta. 2014 May 23;1839(12):1463–1476. doi: 10.1016/j.bbagrm.2014.05.014

Figure 1. Putative mechanisms for how KMTs, KDMs and histone mutations could impact transcriptional regulation.

Figure 1

A. Mutations observed at high rate and/or associated with a functional impact in disease. These mutations are discussed in the text. B. Mutations observed in diseases at low frequency and for which no causal role or association has been reported. We apologize to all those whose work we could not depict or cite due to space limitation.