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. Author manuscript; available in PMC: 2016 Feb 14.
Published in final edited form as: Biochim Biophys Acta. 2014 May 23;1839(12):1463–1476. doi: 10.1016/j.bbagrm.2014.05.014

Figure 2. Crosstalk between histone methylation in diseases.

Figure 2

A. Mutations in EZH2 or MLL4 disrupt the H3K27 and H3K4 trimethylation crosstalk leading to tumorigenesis. B. Mutations in KDM7B or KDM5A disrupt H3K9 and H3K4 methylation leading to XLMR. (i) Schematic depicting how mutation could impact KDM7B recruitment or loss of activity. ? represents the loss of recruitment by methylation or ZNF711. (ii) Schematic depicting how mutations could impact KDM5C function.