Table 3.
Median and interquartile range of cognitive test scores for NACC-database EOAD participants
| EOAD with History of TBI | EOAD without History of TBI | Mann-Whitney U | p-value | |
|---|---|---|---|---|
| Mini-Mental State Examination | 21 (9) | 21 (9) | 95734 | n.s. |
| Logical Memory IA | 4 (6) | 3 (IQR) | 67839 | p < 0.001* |
| Logical Memory IIA | 1 (4) | 0 (3) | 70200 | p < 0.05 |
| Digit Span - Forward | 6 (1.75) | 6 (2) | 86793 | n.s. |
| Digit Span - Backward | 3 (2) | 3 (2) | 85314 | n.s. |
| “Animal” Category Fluency | 11 (8) | 10 (8) | 82655 | n.s. |
| “Vegetable” Category Fluency | 6 (5) | 6 (7) | 85608 | n.s. |
| Boston Naming Test | 24 (8) | 23 (10) | 77974 | n.s. |
| WAIS-R Digit Symbol Subtest | 28 (25) | 23 (25.75) | 49680 | n.s. |
| Trail Making A Test‡ | 54 (69) | 58 (78.25) | 62826 | n.s. |
| Trail Making B Test‡ | 214.5 (205.25) | 240.5 (184) | 32366 | n.s. |
Non-normally distributed. Medians and Interquartile Range (IQR).
*
Still significant after False Discovery Rate correction for multiple comparisons but no longer significant after further accounting for the age differences between the two groups.
‡
Excludes those who did not complete Trail Making A Test in ≤150 s and Trail Making B Test in ≤300 s. TBI, traumatic brain injury; EOAD, early-onset Alzheimer’s disease; WAIS-R, Wechsler Adult Intelligence Scale; n.s. = non-significant.