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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Jan 11;26(4):1265–1271. doi: 10.1016/j.bmcl.2016.01.022

Figure 2. Novel HDAC inhibitors with 4-, 5-, and 6-methylene linkers.

Figure 2

(A) Potent HDAC inhibitors SAHA and crebinostat possess three structural components: surface recognition cap, linker, and a divalent metal (Zn2+) binding element. (B) Novel HDAC inhibitors with 4-, 5-, and 6-methylene linkers and their physicochemical properties. tPSA: topological polar surface area. cLogP: calculated LogP.