Skip to main content
. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Jan 11;26(4):1265–1271. doi: 10.1016/j.bmcl.2016.01.022

Figure 3. In vitro and ex vivo HDAC inhibitory activities of novel HDAC inhibitors with 4-, 5-, and 6-methylene linkers.

Figure 3

(A) In vitro IC50 (nM) with recombinant human HDAC1-3. (B) Increased acetylation of histone H3K9 and H4K12 in mouse forebrain primary neuronal culture (DIV14) detected at both 10 μM and 1 μM (24 hrs). Cellular activity of SAHA at 10 μM was set to 100% as a reference. N=3. Error bars are SEM.