Table 1.

Specific TRP Channels related to respiratory diseases

Channel	Possible Disease Connection	Reference
TRP C1/C6	Asthma, bronchial hyper responsiveness, COPD, idiopathic pulmonary arterial hypertension, heart hypertrophy, mucus hypersecretion	(Nilius, Owsianik et al. 2007, Sel, Rost et al. 2008, Banner, Igney et al. 2011, Grace, Baxter et al. 2014, Kaneko and Szallasi 2014)
TRP V1	Asthma, chronic pain, chronic cough, enhanced airway inflammation and bronchial hyper-reactivity, important sensor of noxious stimuli and tissue damage, bronchoconstriction,	(Caterina, Leffler et al. 2000, Helyes, Elekes et al. 2007, Nilius, Owsianik et al. 2007, Banner, Igney et al. 2011, Billeter, Hellmann et al. 2014, Grace, Baxter et al. 2014, Kaneko and Szallasi 2014)
TRP V4	Chronic pain, asthma, bronchial hyperresponsiveness, hypertension, lung edema by control of epithelial and endothelial barrier function, acute respiratory distress syndrome, COPD, inflammatory airway disease, ventilator induced airway injury	(Michael, Wenjie et al., Freichel, Suh et al. 2001, Liedtke and Friedman 2003, Suzuki, Mizuno et al. 2003, Nilius, Owsianik et al. 2007, Banner, Igney et al. 2011, Grace, Baxter et al. 2014, Jurek, Hirano-Kobayashi et al. 2014, Kaneko and Szallasi 2014)
TRP A1	Chronic pain, asthma, COPD, important sensor of noxious stimuli and tissue damage, allergic and non-allergic airway hyper-responsiveness, increased bronchoconstriction	(Bautista, Jordt et al. 2006, Nilius, Owsianik et al. 2007, Caceres, Brackmann et al. 2009, Banner, Igney et al. 2011, Balakrishna, Song et al. 2014, Billeter, Hellmann et al. 2014, Grace, Baxter et al. 2014, Kaneko and Szallasi 2014)