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. Author manuscript; available in PMC: 2017 Feb 26.
Published in final edited form as: Toxicol Lett. 2015 Nov 10;244:21–27. doi: 10.1016/j.toxlet.2015.11.004

Table 2. Effect of RR on histopathological scores in the lung following CG inhalation exposure in mice at specified time points.

Inhaled CG resulted in the typical pathology of TIH-induced lung injury, and the main pathological characteristics scored are listed in the table below. The effects on the lung histopathological scores of administration of RR after CG inhalation exposure at 12 and 24 hr post-exposure were analyzed, and the median grade of these symptoms following administration when compared to CG alone are shown below.

Time 12 hr 24 hr
Treatment PR PN PR PN
Perivascular edema, +/− inflammation 0 0 0 1
Alveolar exudate Edema 0 0 0 1
Fibrin 1 1 2 3
Hemorrhage 0 0 0 0
Inflammatory cells 0 0 1 1
Alveolar epithelial necrosis 0 0 0 0
Interstitial cellular infiltrate & edema 1 1 2 2
Bronchiolar exudate 0 1 1 3
Bronchiolar epithelial necrosis 0 0 0 1
Perbronchiolar PMN infiltrates & edema 0 0 0 0

PR = phosgene + RR; PN = phosgene no treatment n=10