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. 2016 Jan 18;594(4):985–1003. doi: 10.1113/JP271894

Figure 3. Physiological patterns of Purkinje cell spike firing evoke complex responses in DCN neurons .

Figure 3

Shown are segments of DCN cell recordings with the mean value of presynaptic Purkinje cell stimuli and the number of pulses over the time periods denoted above horizontal bars. A, a Transient burst cell response reveals that IPSP amplitude and the net effect on membrane potential is highly dependent on subtle changes in the presynaptic stimulus ISI. B, a Transient burst cell showing that a cluster of stimuli at ∼127 Hz can elicit a response that satisfies the criteria of rebound burst ISIs (dashed line), but with a delayed onset from the end of the stimulus. A progressive decrease in IPSP amplitude and a depolarizing shift during Purkinje cell input are apparent. C and D, transient burst cells responding to higher frequencies of input exhibit an increase in the ISI (C) or near continuous firing (D) without rebound responses. E, the response of a different Transient burst cell, with the time of a perioral whisker stimulus shown by the horizontal bar. Spike amplitudes are truncated in A, D and E and stimulus artefacts are digitally reduced.