Figure 2. 5‐HT_1A‐receptor desensitization does not determine the decay time of IPSCs .

A, example trace demonstrating a paired‐pulse depression when stimulating at a 4 s interval. B, example trace demonstrating the lack of postsynaptic depression when serotonin was applied by iontophoresis twice at a 4 s interval (Ionto.). C, quantification of amplitude ratio of evoked IPSCs in the absence and presence of the 5‐HT_1B presynaptic receptor antagonist SB 216641 (1 μm) or the current generated by the iontophoresis of serotonin at a 4 s interval. D, representative trace demonstrating the lack of receptor desensitization during evoked IPSCs. Serotonin was applied by iontophoresis during the decay of evoked IPSCs (1 s post‐stimulation; Ionto. 1) and without preceding IPSCs (12 s post‐stimulation; Ionto. 2). E, quantification demonstrating the similar amplitude (left) and time course (right) of currents generated by serotonin iontophoresis in D.