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. 2015 Dec 30;594(4):953–965. doi: 10.1113/JP271716

Figure 3. Serotonin reuptake transporters limit the duration of IPSCs .

Figure 3

A, average 5‐HT1A‐IPSCs under control conditions and in the presence of citalopram (200 nm) and citalopram (200 nm) + SB216641 (1 μm), illustrating that blocking serotonin uptake increased the activation of 5‐HT1A receptors and led to the tonic activation of 5‐HT1B receptors. B, quantification of the change in amplitude of IPSCs induced by citalopram (200 nm) or citalopram (200 nm) + SB216641 (1 μm). C, time course of the relative change in IPSC amplitude quantified in B. D, quantification of the change in kinetics in either citalopram or citalopram + SB 216641. In both cases, inhibiting reuptake transporters prolongs the duration of 5‐HT1A‐IPSCs.