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. 2015 Dec 17;594(4):837–861. doi: 10.1113/JP271394

Figure 6. Both PC‐MC and PC‐BC connections have postsynaptic NMDARs .

Figure 6

A, AMPAR and NMDAR‐mediated currents were measured at latencies indicated by grey boxes (see Methods). These sample sweeps are from a PC‐MC paired recording. Scale bars = 10 ms, 100 pA. B, PC‐BC connections (red) had smaller NMDA/AMPA ratios than PC‐PC (black) or PC‐MC connections (blue), which might appear to suggest that the former have fewer postsynaptic NMDARs. NMDA/AMPA ratios in cells recorded from GIN and WT mice were indistinguishable (0.9 ± 0.06, n = 4 vs. 1.4 ± 0.2, n = 6, P = 0.08). C, in agreement with the existence of postsynaptic NMDARs at PC‐MC connections, an I–V relationship characteristic of an NMDAR‐mediated current was found in the absence (blue) but not the presence of the NMDAR antagonist AP5 (light blue). D, evidence for postsynaptic NMDARs was found at PC‐BC connections as well: an I–V relationship characteristic of the NMDAR‐mediated current was found in the absence (red) but not the presence of the NMDAR antagonist AP5 (pink).