Table 1.

List of isolated alkaloids with plant alkaloids with antidepressant effect.

Plant name	Structure	Mechanism	References
Berberis aristata	Berberine	Serotonergic, noradrenergic, and dopaminergic interventions	Kulkarni and Dhir, 2008; Lee et al., 2012
Psychotria myriantha	Strictosidine acid	MAO inhibition	Farias et al., 2012
Annona cherimolia	Anonaine Liriodenine	Increase in monoaminergic turnover	Martínez-Vázqueza et al., 2012
Rhazya stricta	Akuammine	MAOA inhibition	Ali et al., 1998
Mitagyna speciosa	Mitagynine	Reducing the release of corticosterone	Idayu et al., 2011
Peganum harmala	Norharmane Harmane Harmine	Interfering with MAO-A and several cell-surface receptors, including serotonin receptor 2A	Farzin and Mansouri, 2006
Ziziphus apetala	Mauritine A	11-β-hydroxysteroid dehydrogenase inhibition	Han et al., 2011
Aconitum baicalense	Songorine	Improved serotonergic system	Nesterova et al., 2011
Boerhaavia diffusa	Punarnavine E	MAO inhibition and decreased plasma corticosterone level	Dhingra and Valecha, 2014
Evodia fructus	Evodiamine	Effects on the monoamine transmitters and BDNF-TrkB signaling in the hippocampus	Jiang et al., 2015
Sceletrium tortuosum	Mesembrine	5HT reuptake inhibition	Loria et al., 2014
Piper nigrum	Piperine	Inhibition of MAO enzymes, elevation of brain 5-HT and BDNF levels	Wattanathorn et al., 2008
Piper laetispicum	Leatispicine LeatispiamideA	Mechanism not studied yet	Yao et al., 2009
Dactylicapnos scanens	protopine	Inhibition of serotonin transporter and Noradrenaline transporter	Xu et al., 2006