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. 2016 Feb 1;2016:8648356. doi: 10.1155/2016/8648356

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Copyright © 2016 Nidal Ghosheh et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Morphology of cells during hepatic differentiation at days 0, 5, 7, 9 (ChiPSC6b), 11 (P11012), 14 (ChiPSC6b), 16 (P11012), 18 (P11012), 21 (P11012), 24 (SA121), 29 (AS034), and 35 (ChiPSC6b) magnification 10x. (a) Human PSCs cultured in Cellartis DEF-CS demonstrate stem cell morphology at day 0 (AS034). (b) At day 5 (P11025) and day 7 (SA181) the cells show a characteristic DE morphology. (c) Following the application of HEP progenitor medium, the DE cells transferred gradually to hepatoblasts. (d) The cells acquired the hepatocyte morphology (polygonal cells) following the application of HEP maturation medium (3Ap) and supplement (3Bp). In the HEP maintenance medium (4) the cells preserve typical hepatocyte morphology, polygonal cells with single- or binucleus.