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. 2016 Mar;8(2):113–125. doi: 10.1177/1758834015616935

Table 2.

Key randomized phase III trial with targeted agents in previously untreated gastric cancer.

Trial name Selected biomarker Treatment Number of patients Primary endpoint Hazard ratio (95% confidence interval) p value Median OS (months)
ToGA[Bang et al. 2010] HER2 expression/amplification CF/CXCF/CX +trastuzumab 290294 OS 0.74 (0.60–0.91) 0.004 13.811.1
LOGiC[Hecht et al. 2013] HER2 expression/amplification CapeOXCapeOx+lapatinib 273272 OS 0.91 (0.73–1.12) 0.35 10.512.2
REAL-3 all comers EOX 275 OS 1.37 (1.07–1.76) 0.013 11.3
[Waddell et al. 2013] EOX+panitumumab 278 8.8
EXPAND all comers CX 449 PFS 1.09 (0.92–1.29) 0.32 10.7
[Lordick et al. 2013] CX+cetuximab 445 9.4
RILOMET[Cunningham et al. 2015] MET positive by IHC HER2 negative ECXECX+rilotumumab 305304 OS 1.37 (1.06–1.78) 0.016 11.5 9.6
AVAGAST all comers CX 387 OS 0.87 (0.73–1.03) 0.1 10.1
[Ohtsu et al. 2011] CX+bevacizumab 387 12.1
AVATAR all comers CX 102 OS 1.11 (0.79–1.56) 0.5567 11.4
[Shen et al. 2015] CX+bevacizumab 100 10.5

CapeOX, capecitabine, oxaliplatin; CF, cisplatin, fluorouracil; CX, cisplatin, capecitabine; ECX, epirubicin, cisplatin and capecitabine; EOX, epirubicine, oxaliplatin, capecitabine; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; OS, overall surivial; PFS, progression-free survival.