Table 7.

Average number of clusters of cells or vascularized metastases at week 5 for 4T1 mouse syngeneic breast model of metastasis.

Drug	Micrometastases	Large micrometastases	Macrometastases
Untreated	59 ± 6.5	8.2 ± 1.4	1.17 ± 0.3
Doxorubicin	31 ± 5.6	4.1 ± 1.1	0.77 ± 0.3
DT310	29 ± 7.4	0.6 ± 0.4 (p < 0.01)	0.26 ± 0.4 (p < 0.01)
DT320	29 ± 6.6	2.4 ± 0.7 (p < 0.01)	0.40 ± 0.2 (p < 0.05)

The p values listed are in comparison with doxorubicin. All differences in comparison with untreated animals were significant at p < 0.01 except macrometastases with doxorubicin (p < 0.05). The effect of all agents versus untreated on micrometastases was significant at p < 0.05.