Figure 7.

Predicted effects on clearance time (by PCR) of increasing the initial frequency of the slowest clearing parasite subpopulation in individual infections. (A) The predicted effects on five of the patients from Tanzania in which significant variation in clearance rates was observed. One patient is plotted on its own (B) for visibility. (Note that the simulations assume that all relevant rates remain constant, i.e. there are no changes in pharmacokinetics/pharmacodynamics nor other within-host processes, over the relevant timescale. This is likely to be violated over the span of 100 days but does not affect our inference of having detected some very slow clearing subpopulations.)