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. 2015 Dec 21;37(2):166–176. doi: 10.1038/aps.2015.111

Figure 6.

Figure 6

YY-23 reversed the depressive-like behavior induced by CMS and CSDS with rapid onset. (A) YY-23 and fluoxetine (FLX) reversed the immobility deficit of TST induced by CMS stimulation, YY-23 showed an earlier onset than FLX by 1 week. (B) YY-23 and FLX reversed the decreased sucrose consumption in SPT induced by CMS in 3 weeks. Parameters of the immobility in TST and the sucrose consumption in SPT were measured each week. The result of week 1 is not shown. (C) All of the mice exhibited normal locomotor activity represented by walking speed in open field test. (D) All of the mice exhibited normal locomotor activity represented by total distance walked in OFT. (E) YY-23 reversed the decreased social interaction ratio caused by CSDS within 1 week, whereas FLX failed to reverse the social deficit in 3 weeks. Data were represented as the mean±SEM. aP>0.05, bP<0.05, cP<0.01 vs CON; dP>0.05, eP<0.05, fP<0.01 vs CMS (or DEFEAT).