Figure 5.

Ginkgolide B suppresses pro-inflammatory response factors in HUVECs. (A–D) HUVECs pretreated with ginkgolide B (30, 150, or 300 μmol/L) for 24 h in the presence or absence of PXR siRNA before exposure to TNF-α (10 ng/mL). (A, B) VCAM-1 and E-selectin mRNA were measured by qRT-PCR. (C, D) VCAM-1 and E-selectin protein expression was measured with Western blot. Data shown are mean±SEM. n=3. ^cP<0.01 vs control. ^dP>0.05, ^eP<0.05 vs MOCK group. ^hP<0.05 vs PXR siRNA group. MOCK' group: MOCK+siRNA.