Figure 5.

VPA inhibited cell proliferation and extracellular matrix synthesis in HMCs induced by P-aIgA1 by modulating the TGF-β/pSmad2/3 and Jak2/pStat3 signaling pathways. The expression of HDAC1 in HMCs of different groups was detected by Western blotting (A) and immunofluorescence (B). The expression of Stat3 and pStat3 (C) and Smad2/3 and pSmad2/3 (E) in HMCs of different groups was detected by Western blotting. Mean±SEM. n=3. ^cP<0.01 vs control group; ^eP<0.05, ^fP<0.01 vs P-aIgA1 group.