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. 2016 Feb 15;6:6. doi: 10.3389/fcimb.2016.00006

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Copyright © 2016 Sershen, Plimpton and May.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Containment granuloma with TNFα, contains bacteria characterizable as in a state comparable to non-replicating persistence at 500 days. (A) Partial pressure of oxygen across the granuloma (B) oxygen depletion rate (C) bacterial growth rates for extracellular (D) and intracellular (E) bacteria; scaled NAD/NADH ratio for both extracellular (F) and intracellular (G) bacteria; change in ATP concentration for extracellular (H) and intracellular (I) bacteria.