Table 5.
Containment and dissemination parameters for simulation runs used in sensitivity analysis.
| Description | Units | Containment (Mean) | Containment (Min) | Containment (Max) | Dissemination (Mean) | Dissemination (Min) | Dissemination (Max) |
|---|---|---|---|---|---|---|---|
| Probability a resting macrophage kills a bacterium in his compartment | Per 10 minutes | 0.0541 | 0.0131 | 0.0972 | 0.0486 | 0.0162 | 0.0781 |
| Probability a macrophage is recruited from a vascular source | Per 10 minutes | 0.0661 | 0.0213 | 0.1405 | 0.0631 | 0.0188 | 0.1294 |
| Probability a T cell is recruited at a vascular source | Per 10 minutes | 0.0542 | 0.011 | 0.137 | 0.109 | 0.0754 | 0.1415 |
| Proportion of T cells recruited that are regulator T cells | Per 10 minutes | 0.0763 | 0.0125 | 0.1562 | 0.152 | 0.0208 | 0.196 |
| Chemokine diffusion constant | cm2/per second | 6.00E-08 | 1.86E-08 | 1.07E-07 | 7.89E-08 | 3.29E-08 | 1.05E-07 |
| Chemokine halflife | Hours | 1.45 | 0.64 | 2.24 | 1.49 | 0.77 | 2.27 |
| CCL5 secretion | No. molecules secreted hourly | 2.78E+05 | 7.53E+04 | 4.59E+05 | 2.60E+05 | 6.34E+04 | 4.37E+05 |
| TNF diffusion constant | cm2/per second | 4.31E-08 | 1.99E-08 | 1.01E-07 | 7.87E-08 | 2.56E-08 | 1.12E-07 |
| TNF halflife | Hours | 7.12 | 1.19 | 11.17 | 5.22 | 2.31 | 8.42 |
| Probability a macrophage undergoes apoptosis | Per 10 minutes | 0.13 | 0.08 | 0.19 | 0.1 | 0.04 | 0.18 |
| Threshold required for macrophage recruitment | Checked every ten minutes | 6.96E+05 | 1.97E+05 | 1.44E+06 | 1.08E+06 | 8.27E+05 | 1.45E+06 |
| Oxygen in lung tissue due to pulmonary blood volume | Steady-state number of molecules | 5.68E+08 | 2.81E+08 | 9.42E+08 | 5.76E+08 | 3.43E+08 | 8.39E+08 |
| Oxygen in lung tissue due to residual volume in lung | Steady-state number of molecules | 9.53E+08 | 4.02E+08 | 1.35E+09 | 8.61E+08 | 6.09E+08 | 1.09E+09 |
| Oxygen consumption by a resting macrophage | Number of molecules per 1 breath | 7.19E+07 | 6.16E+07 | 8.15E+07 | 7.55E+07 | 5.88E+07 | 9.46E+07 |
| Oxygen consumption by bacteria | Number of molecules per 1 breath | 8.77E+05 | 5.50E+05 | 1.15E+06 | 8.07E+05 | 4.90E+05 | 9.98E+05 |
| Oxygen diffusion coefficient | cm2/per second | 5.83E-05 | 5.98E-06 | 1.10E-04 | 5.03E-05 | 5.38E-06 | 8.82E-05 |
| TNF threshold necessary to activate a macrophage | Checked every 10 min | 1.82E+05 | 6.68E+03 | 3.18E+05 | 2.02E+05 | 4.09E+04 | 3.44E+05 |
| Probability an infected macrophage becomes activated | Per 10 minutes | 2.92E-02 | 3.37E-04 | 7.52E-02 | 3.05E-03 | 3.14E-04 | 8.91E-03 |
| Probability a T cell moves into a compartment occupied by a macrophage | Per 10 minutes | 1.65E-03 | 1.90E-05 | 8.18E-03 | 2.91E-02 | 1.03E-05 | 8.88E-02 |
| TNF/chemokine threshold for T cell recruitment at a vascular source | Checked every 10 min | 1.73E+04 | 1.17E+03 | 8.13E+04 | 7.73E+03 | 2.64E+03 | 1.55E+04 |
| TNF/chemokine threshold for macrophage recruitment at a vascular source | Checked every 10 min | 1.32E+04 | 1.24E+03 | 8.76E+04 | 7.19E+03 | 1.39E+03 | 2.30E+04 |
| Lower threshold for recruitment of CCL5 | Checked every 10 min | 3.09E+05 | 1.75E+04 | 7.18E+05 | 1.28E+05 | 1.69E+04 | 4.40E+05 |
| Upper threshold for recruitment of CCL5 | Checked every 10 min | 1.83E+05 | 1.22E+04 | 6.79E+05 | 3.68E+04 | 1.58E+04 | 6.60E+04 |
| TNF secretion | No. molecules per 10 min | 5.33E+06 | 9.50E+04 | 2.87E+07 | 3.82E+06 | 2.09E+04 | 1.67E+07 |
| Effect of TNF on resting macrophage recruitment | Checked every 10 min | 225.53 | 12 | 706.96 | 255 | 16.39 | 875.23 |
| Maximum specific growth rate | Hourly | 0.0127 | 0.0024 | 0.0386 | 0.0343 | 0.0305 | 0.0379 |
| Maximum specific death rate | Hourly | 0.0004 | 0.0001 | 0.0008 | 0.0006 | 0.0004 | 0.0007 |