Table 2. Cox Regression Model: Overall survival.
| NTUH |
MMH |
NTUH/MMH Summary Analysis |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | |
| LKB1(IHC) | 0.321 | 0.823 | 0.419 | ||||||
| Negative | 1.000 | 1.000 | 1.000 | ||||||
| Positive | 0.766 | 0.453–1.296 | 1.054 | 0.665–1.671 | 0.868 | 0.615–1.224 | 0.419 | ||
| ER | 0.001* | 0.064 | <0.0001* | ||||||
| Negative | 1.000 | 1.000 | 1.000 | ||||||
| Positive | 0.369 | 0.210–0.648 | 0.620 | 0.374–1.028 | 0.523 | 0.365–0.748 | |||
| HER2 | 0.233 | 0.247 | 0.211 | ||||||
| Negative | 1.000 | 1.000 | 1.000 | ||||||
| Positive | 0.690 | 0.375–1.269 | 0.753 | 0.466–1.217 | 0.790 | 0.547–1.142 | |||
| T | 0.193 | <0.0001* | <0.0001* | ||||||
| T1 | 1.000 | 1.000 | 1.000 | ||||||
| T2 | 1.657 | 0.910–3.016 | 0.098 | 0.732 | 0.424–1.263 | 0.262 | 1.169 | 0.785–1.742 | 0.442 |
| T3 | 2.114 | 0.838–5.334 | 0.113 | 1.901 | 0.820–4.404 | 0.134 | 1.716 | 0.951–3.096 | 0.073 |
| T4 | 2.881 | 0.811–10.232 | 0.102 | 3.499 | 1.502–8.150 | 0.004 | 3.976 | 2.038–7.757 | <0.0001 |
| N | 0.007* | <0.0001* | <0.0001* | ||||||
| N0 | 1.000 | 1.000 | 1.000 | ||||||
| N1 | 1.349 | 0.742–2.450 | 0.326 | 2.325 | 1.231–4.390 | 0.009 | 1.744 | 1.139–2.671 | 0.011 |
| N2 | 3.088 | 1.444–6.601 | 0.004 | 4.186 | 2.130–8.226 | <0.0001 | 4.587 | 2.895–7.269 | <0.0001 |
| N3 | 3.292 | 1.356–7.991 | 0.008 | 5.329 | 2.730–10.399 | <0.0001 | 6.004 | 3.712–9.711 | <0.0001 |
| Grade | 0.809 | 0.361 | 0.105 | ||||||
| Grade 1 | 1.000 | 1.000 | 1.000 | ||||||
| Grade 2 | 1.257 | 0.574–2.752 | 0.567 | 2.692 | 0.630–11.510 | 0.182 | 1.955 | 1.005–3.805 | 0.048 |
| Grade 3 | 1.327 | 0.557–3.161 | 0.523 | 2.946 | 0.668–13.002 | 0.154 | 2.127 | 1.051–4.306 | 0.036 |
| Menopause | 0.083 | 0.105 | 0.006* | ||||||
| Negative | 1.000 | 1.000 | 1.000 | ||||||
| Positive | 1.586 | 0.941–2.674 | 1.501 | 0.918–2.453 | 1.631 | 1.149–2.317 | |||
| METBRIC Discovery Cohort | METBRIC Validation Cohort | ||||||||
| HR | 95%CI | P | HR | 95%CI | P | ||||
| LKB1(mRNA) | 0.512 | 0.816 | |||||||
| Negative | 1.000 | 1.000 | |||||||
| Positive | 0.937 | 0.772–1.138 | 0.512 | 1.024 | 0.839–1.250 | 0.816 | |||
| ER | 0.050* | 0.080 | |||||||
| Negative | 1.000 | 1.000 | |||||||
| Positive | 0.770 | 0.593–1.000 | 0.794 | 0.613–1.028 | |||||
| HER2 | 0.008* | 0.521 | |||||||
| Negative | 1.000 | 1.000 | |||||||
| Positive | 1.479 | 1.110–1.972 | 1.101 | 0.821–1.476 | |||||
| T | 0.007* | <0.0001* | |||||||
| T1 | 1.000 | 1.000 | |||||||
| T2 | 1.334 | 1.076–1.653 | 0.009 | 1.701 | 1.369–2.114 | <0.0001 | |||
| T3 | 1.798 | 1.129–2.864 | 0.013 | 2.381 | 1.600–3.543 | <0.0001 | |||
| N | <0.0001* | <0.0001* | |||||||
| N0 | 1.000 | 1.000 | |||||||
| N1 | 1.307 | 1.038–1.647 | 0.023 | 1.385 | 1.102–1.740 | 0.005 | |||
| N2 | 2.112 | 1.594–2.799 | <0.0001 | 2.060 | 1.508–2.814 | <0.0001 | |||
| N3 | 4.343 | 2.682–7.032 | <0.0001 | 3.433 | 2.370–4.973 | <0.0001 | |||
| Grade | 0.713 | 0.240 | |||||||
| Grade 1 | 1.000 | 1.000 | |||||||
| Grade 2 | 1.044 | 0.664–1.640 | 0.852 | 1.381 | 0.926–2.060 | 0.113 | |||
| Grade 3 | 1.134 | 0.719–1.788 | 0.590 | 1.411 | 0.937–2.124 | 0.099 | |||
| Menopause | 0.001* | 0.008* | |||||||
| Negative | 1.000 | 1.000 | |||||||
| Positive | 1.543 | 1.194–1.994 | 1.443 | 1.099–1.894 | |||||