Table 3. Cox Regression Model: Breast Cancer Specific Survival.

	METBRIC Discovery Cohort			METBRIC Validation Cohort
	HR	95%CI	P	HR	95%CI	P
LKB1(mRNA)			0.856			0.282
Negative	1.000			1.000
Positive	0.977	0.761–1.255		0.865	0.665–1.126
ER			0.054			0.021*
Negative	1.000			1.000
Positive	0.726	0.524–1.005		0.680	0.490–0.943
HER2			0.003*			0.056
Negative	1.000			1.000
Positive	1.669	1.186–2.348		1.393	0.991–1.959
T			0.049*			<0.0001*
T1	1.000			1.000
T2	1.316	0.991–1.747	0.058	1.709	1.271–2.299	<0.0001
T3	1.841	1.051–3.223	0.033	2.287	1.390–3.761	0.001
N			<0.0001*			<0.0001*
N0	1.000			1.000
N1	1.628	1.201–2.208	0.002	1.787	1.299–2.459	<0.0001
N2	2.771	1.945–3.948	<0.0001	3.223	2.163–4.803	<0.0001
N3	5.483	3.057–9.836	<0.0001	5.244	3.380–8.135	<0.0001
Grade			0.182			0.042*
Grade 1	1.000			1.000
Grade 2	1.266	0.651–2.459	0.487	2.655	1.223–5.765	0.014
Grade 3	1.585	0.817–3.075	0.173	2.690	1.227–5.898	0.013
Menopause			0.977			0.633
Negative	1.000			1.000
Positive	0.996	0.738–1.344		0.926	0.674–1.271