Table 1.
Historical perspective of major findings of SYNGAP1.
| Observation/findings of SYNGAP1 | Referrences | Model/samples |
|---|---|---|
| First Syngap1 Het mouse model | Chen et al. (1998) | Mouse |
| Binds to CaMKII /PSD95 | Chen et al. (1998) | Mouse |
| Kim et al. (1998) | Yeast two-hybrid hippocampal cDNA library | |
| Amino acid sequences and molecular weight | Chen et al. (1998) | Mouse |
| Kim et al. (1998) | Yeast two-hybrid hippocampal cDNA library | |
| Husi et al. (2000) | Mouse | |
| McMahon et al. (2012) | Mouse | |
| Domain structure of SYNGAP1 and Isoforms | Chen et al. (1998) | Mouse |
| McMahon et al. (2012) | Mouse | |
| Localized in excitatory neurons | Chen et al. (1998) | Mouse |
| Kim et al. (1998) | ||
| Kim et al. (1998) | Yeast two-hybrid hippocampal cDNA library | |
| Syngap1 Homozygous mice die within a week | Komiyama et al. (2002) | Mouse/Primary neuronal culture |
| Kim et al. (2003) | Mouse/cortical culture | |
| Synaptic transmission and LTP | Komiyama et al. (2002) | Mouse/Primary neuronal culture |
| Kim et al. (2003) | Mouse/cortical culture | |
| Learning and Memory deficits | Komiyama et al. (2002) | Mouse/Primary neuronal culture |
| Altered ERK, Ras, Rac p-Cofilin | Komiyama et al. (2002) | Mouse/Primary neuronal culture (ERK) |
| Carlisle et al. (2008) | Mouse/Hippocampi neuronal culture | |
| Dendritic spine structure | Vazquez et al. (2004) | Mouse/primary neuronal culture |
| Carlisle et al. (2008) | Mouse/Hippocampi neuronal culture | |
| Cognitive and social dysfunction | Guo et al. (2009) | Mouse |
| Muhia et al. (2010) | Mouse | |
| Intellectual disability in children | Hamdan et al. (2009) | Human |
| Prematuration of dendritic spines | Clement et al. (2012) | Mouse |
| Aceti et al. (2015) | Mouse (in vivo) | |
| Altered critical period of plasticity | Clement et al. (2013) | Mouse |
This table summarizes the major findings/observations of function of SYNGAP1 by various groups.