Table 1. Activity of disorazol A₁ and disorazol A₂ against human cancer cell lines.

Human Cell line	Origin	IC50 [nM]
		Disorazol A1	Disorazol A2
A-431	epidermoid carcinoma	1.866	4.908
A-549	lung carcinoma	0.072	0.408
HCT-116	colon carcinoma	0.032	0.071
HepG2	hepatocellular carcinoma	0.002	0.051
HL-60	acutemyeloid leukemia	0.058	0.084
K-562	chronicmyeloid leukemia	0.074	0.140
KB-3.1	cervix carcinoma	0.025	0.106
SW480	colonadeno carcinoma	0.030	0.128
U-2 OS	osteosarcoma	0.038	0.206
U-87 MG	glioblastoma-astrocytoma	0.072	0.119
U-937	histiocytic lymphoma	0.293	0.210

IC₅₀ values refer to antiproliferative activities.