Table 1. Activity of disorazol A1 and disorazol A2 against human cancer cell lines.
Human Cell line | Origin | IC50 [nM] |
|
---|---|---|---|
Disorazol A1 | Disorazol A2 | ||
A-431 | epidermoid carcinoma | 1.866 | 4.908 |
A-549 | lung carcinoma | 0.072 | 0.408 |
HCT-116 | colon carcinoma | 0.032 | 0.071 |
HepG2 | hepatocellular carcinoma | 0.002 | 0.051 |
HL-60 | acutemyeloid leukemia | 0.058 | 0.084 |
K-562 | chronicmyeloid leukemia | 0.074 | 0.140 |
KB-3.1 | cervix carcinoma | 0.025 | 0.106 |
SW480 | colonadeno carcinoma | 0.030 | 0.128 |
U-2 OS | osteosarcoma | 0.038 | 0.206 |
U-87 MG | glioblastoma-astrocytoma | 0.072 | 0.119 |
U-937 | histiocytic lymphoma | 0.293 | 0.210 |
IC50 values refer to antiproliferative activities.