Table 2.
Group Comparisons of Metabolite Concentrations in the Hippocampus and ACC
| Metabolite | Hippocampus | ACC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls (n = 29)a | Patients (n = 29)a | Statistics | Controls (n = 29)a | Patients (n = 29)a | Statistics | |||||
| Meanb (SD) | Meanb (SD) | F/t c | Df | P | Meanb (SD) | Meanb (SD) | F/t c | df | P | |
| Glutamate | 10.42 (1.53) | 12.10 (1.47) | 14.58 | 1 | <.001 | 15.17 (1.11) | 14.46 (1.56) | 5.56 | 1 | .022 |
| NAA | 11.43 (1.04) | 11.04 (0.80) | 5.26 | 1 | .026 | 13.23 (1.17) | 12.70 (0.99) | 5.22 | 1 | .026 |
| Choline | 2.34 (0.25) | 2.37 (0.26) | 0.027 | 1 | .869 | 2.42 (0.27) | 2.26 (0.27) | 4.01 | 1 | .048 |
| Creatine | 9.47 (0.90) | 9.85 (1.14) | 1.24 | 1 | .270 | 10.59 (0.89) | 10.17 (1.00) | 2.61 | 1 | .112 |
| Grey matter | 0.61 (0.06) | 0.63 (0.05) | 1.32 | 56 | .192 | 0.56 (0.03) | 0.57 (0.03) | 1.49 | 56 | .141 |
| White matter | 0.33 (0.06) | 0.31 (0.05) | -1.2 | 56 | .234 | 0.27 (0.04) | 0.29 (0.05) | 2.32 | 56 | .024 |
| CSF | 0.06 (0.02) | 0.06 (0.02) | -0.32 | 56 | .747 | 0.17 (0.03) | 0.14 (0.04) | -3.86 | 56 | <.001 |
Note: ACC, anterior cingulate cortex; CSF, cerebral spinal fluid.
a29 patients and 29 controls were included in the sample. Owing to insufficient spectra quality, some results are missing: 2 for Glu, 1 for tCho, and 1 for tCr from hippocampus of controls and 1 for tCr from ACC of patients.
bMean concentrations in mmol/l.
c F for Glu, NAA, tCho, andtCr. Student’s t for grey matter, white matter, and CSF.