Table 3.
Mean Levels of a Priori and Exploratory FA Between Patients, Siblings, Controls
| Patients (N = 215) | Siblings (N = 187) | Controls (N = 98) | F a | P a | |
|---|---|---|---|---|---|
| Mean (SD)b | Mean (SD)b | Mean (SD)b | |||
| A priori FA | |||||
| C22:6w3 DHA | 16.4 (5.1) | 17.7 (5.0) | 16.0 (5.5) | 2.46 | .087 |
| C22:5w3 DPA | 9.7 (2.0) | 9.3 (2.2) | 8.5 (2.0) | 6.47 | .002 |
| C20:4w6 AA | 76.4 (11.2) | 77.1 (10.2) | 71.7 (9.6) | 7.98 | <.001 |
| C18:2w6 LA | 64.3 (12.7) | 64.6 (11.5) | 60.8 (9.5) | 2.33 | .098 |
| C24:1w9 NA | 18.1 (3.9) | 18.8 (4.0) | 16.4 (3.4) | 11.06 | <.001 |
| C20:5w3 EPA | 2.8 (1.3) | 2.8 (1.5) | 2.5 (1.5) | 1.42 | .243 |
| Exploratory FA c | |||||
| C14:0 | 2.8 (1.2) | 2.9 (1.1) | 2.7 (1.2) | 0.80 | .450 |
| C16:0 | 148.3 (19.7) | 150.3 (20.1) | 142.5 (17.4) | 3.67 | .026 |
| C18:0 | 100.6 (11.7) | 100.2 (11.6) | 96.2 (11.0) | 4.67 | .010 |
| C20:0 | 2.4 (0.4) | 2.4 (0.4) | 2.3 (0.4) | 3.88 | .021 |
| C22:0 | 8.9 (1.6) | 9.1 (2.7) | 8.5 (1.4) | 4.05 | .018 |
| C24:0 | 20.4 (4.4) | 20.3 (4.3) | 18.8 (4.0) | 5.50 | .004 |
| C18:3w3 | 0.7 (0.3) | 0.8 (0.4) | 0.7 (0.3) | 4.09 | .017 |
| C18:4w3 | 0.2 (0.2) | 0.2 (0.2) | 0.2 (0.2) | 0.21 | .810 |
| C14:1w5 | 0.6 (0.9) | 0.6 (0.9) | 0.5 (0.7) | 1.54 | .215 |
| C20:2w6 | 1.3 (0.4) | 1.4 (0.4) | 1.3 (0.3) | 1.19 | .306 |
| C20:3w6 | 9.9 (2.7) | 9.6 (2.2) | 8.8 (2.0) | 4.95 | .008 |
| C22:4w6 | 13.4 (3.2) | 13.8 (3.2) | 12.6 (2.9) | 7.34 | .001 |
| C22:5w6 | 2.4 (0.8) | 2.5 (0.8) | 2.2 (0.7) | 3.46 | .032 |
| C16:1w7 | 2.2 (1.3) | 2.2 (1.2) | 1.8 (0.8) | 2.36 | .095 |
| C18:1w7 | 7.1 (1.3) | 7.3 (1.3) | 6.8 (1.1) | 5.27 | .006 |
| C20:1w7 | 0.5 (0.6) | 0.6 (0.8) | 0.6 (0.7) | 1.52 | .221 |
| C16:1w9 | 1.0 (0.6) | 1.0 (0.5) | 1.0 (0.5) | 0.07 | .937 |
| C18:1w9 | 71.3 (10.8) | 72.0 (13.0) | 66.5 (12.8) | 7.48 | .001 |
| C20:1w9 | 1.3 (0.5) | 1.3 (0.4) | 1.4 (0.8) | 1.15 | .319 |
| C20:3w9 | 0.4 (0.3) | 0.3 (0.2) | 0.3 (0.2) | 2.56 | .078 |
| C22:1w9 | 3.5 (4.5) | 3.2 (2.5) | 3.0 (2.0) | 0.31 | .733 |
| Total FA | 588.8 (70.8) | 593.2 (70.3) | 556.1 (62.1) | 8.60 | <.001 |
| Total AA/Total DHA | 5.1 (1.6) | 4.7 (1.3) | 4.9 (1.6) | 0.55 | .576 |
| Total w6/Total w3 a priori FA |
5.1 (1.2) | 5.0 (1.2) | 5.2 (1.3) | 1.90 | .150 |
| Total w6/Total w3 all FA |
5.8 (1.3) | 5.7 (1.3) | 5.6 (1.6) | 0.17 | .846 |
Note: AA, Arachidonic Acid; BMI, Body Mass Index; DPA, Docosapentaenoic Acid; DHA, Docosahexaenoic Acid; EPA, Eicasopentaenoic Acid; FA, Fatty Acid; IQ, intelligence quotient; LA, linoleic acid.
aAdjusted for gender, IQ, BMI, tobacco use.
bConcentrations of FA are given as picomol/106 erythrocytes.
cSubstitution of nondetectable values with 0.