Table 2.

Association Results for rs6579797 and WWC1 Variants for Select Cognitive Measures in Mexican American Families

T2D-GENES Families (n = 959)			IQ				CVLT
			WASI-II (n = 430)		WTAR VIQ (n = 264)		Total Recall (n = 520)		Delayed Recall (n = 518)
dbSNP 137	Gene	MAF	Beta (SE)	P Value	Beta (SE)	P Value	Beta (SE)	P Value	Beta (SE)	P Value
rs6579797	SYNPO	0.022	−6.28 (2.79)	.025	−7.54 (2.96)	.011	−1.55 (1.96)	.43	−0.38 (0.56)	.50
rs17551608	WWC1	0.077	−2.86 (1.78)	.11	0.74 (1.53)	.63	−1.60 (1.26)	.20	−0.52 (0.36)	.15
rs61730019	WWC1	0.015	1.58 (3.71)	.67	5.24 (3.71)	.16	7.63 (2.57)	.0031	1.93 (0.74)	.0091

^{Note: The table presents association results between SYNPO and WWC1 variants and measures of IQ and verbal memory in Mexican American families using whole genome sequences and imputed data from the T2D-GENES consortium. Two measures of IQ were tested for genetic association: WAIS II and WTAR verbal IQ. For verbal memory, total and delayed recalls for the CVLT were examined. MAFs are based on maximum likelihood estimates that account for familial relationships. Significant association P values (< .05) are highlighted in bold. CVLT, California Verbal Learning Test; IQ, Intelligent quoteint; MAFs, Minor allele frequencies; WAIS, Wechsler Adult Intelligence Scale; WTAR, Wechsler Test of Adult Reading.}