FIG. 1.

Treatment with SOD3-transduced MSCs inhibits epidermal hyperproliferation, decreases acanthosis, and reduces the disease severity in psoriasis mouse model. (A) An experimental setup and (B) phenotypical presentation of mouse back skin after 6- and 12-day regimens are shown. Measurement of epidermal thickness (C) and hematoxylin and eosin staining of the back skin of mice (D). Data are represented as mean ± SD. ^###p < 0.001 (control group vs. IMQ-treated group in all cases); *p < 0.05, **p < 0.01, ***p < 0.001 (IMQ-treated group vs. MSC-treated group in all cases). Scale bar, 100 μm. IMQ, imiquimod; MSCs, mesenchymal stem cells; SD, standard deviation; SOD3, extracellular superoxide dismutase. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars