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. 2016 Feb 1;26(1):29–43. doi: 10.1089/nat.2015.0566

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© Estefanía Mondragón et al, 2015; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (<http://creativecommons.org/licenses/by/4.0>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 11. — Proposed inhibition mechanism for two anti-TATA-binding protein (TBP) RNA aptamers. (A) Aptamer selected against TBP DNA-binding site acts as a competitive inhibitor preventing transcription by sequestering TBP. (B) Aptamers selected against a TBP-TATA complex are proposed to bind the TBP surface, preventing its interaction with other factors, for example, TFIIB, hence suppressing transcription.