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. 2016 Feb 1;26(1):29–43. doi: 10.1089/nat.2015.0566

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© Estefanía Mondragón et al, 2015; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (<http://creativecommons.org/licenses/by/4.0>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 9. — RNAs that regulate nuclear receptors. (A) Schematic secondary structure of growth arrest-specific 5 (Gas5) nucleotides 400–598. Gas5 (400–598) consists of six hairpin structures. Hairpin 5 is proposed to contain two glucocorticoid response element (GRE) sequences at nucleotides 539–544 and 553–559 (shown in red), which form a double-stranded hairpin structure that may mimic a GRE in dsDNA. Gas5 hairpin 3 is proposed to contain an MRE mimic (highlighted in purple at nucleotides 540–554). These residues are conserved among the consensus DNA GREs and are thought to be critical for interaction with residues of the glucocorticoid receptor DNA binding domain. Adapted from Kino [113]. (B) Three SRA1 complementary DNAs (cDNAs) sharing a central core region, but different in their 5′ and 3′ extremities and below a schematic representation of the proposed steroid receptor RNA activator (SRA) RNA secondary structures and assigned motifs. Adapted from Refs. [164,165].