Table 1.
Natural RNAs That Regulate Transcription Factors
| RNA | TF target | Regulation |
|---|---|---|
| 5S RNA | TFIIIA | Its own transcription |
| 6S RNA | σ70-RNAp | Wide-range regulation of transcription of several genes |
| 3′ UTR of cad | Bicoid | Expression of caudal |
| TSU | STAT1 | Reduces nuclear translocation and suppression of MHC genes |
| NRSE-RNA | NRSF/REST | Inhibits REST from binding to dsDNA and acting as a repressor |
| HSR1 | HSF1 | Stimulates heat shock response by stabilizing HSF1 |
| HDV | RNAP II | Regulates its own transcription |
| 7SK | HMGA1 | Inhibits HMGA1 binding to dsDNA |
| ncRNA anti-p53 | p53 | Fine tunes p53 response |
| Gas5 | GR | Reduces GR response |
| SRA | SRA | Activates SRA response by acting as a scaffold |
Gas5, growth arrest-specific 5; GR, glucocorticoid receptor; HDV, hepatitis delta virus; HMGA1, high mobility group protein A1; HSF1, heat shock transcription factor 1; HSR1, heat shock RNA-1; MHC, major histocompatibility complex; NRSE, neuron restrictive silencer element; NRSF, neuron-restrictive silencer factor; REST, RE1-silencing transcription factor; RNAP II, RNA polymerase II; SRA, steroid receptor RNA activator; STAT1, signal transducers and activators of transcription; TF, transcription factor; TSU, trophoblast STAT utron; UTR, untranslated region.