Table 2.
Selected RNAs That Regulate Transcription Factors
RNA aptamer | Target | Potential application |
---|---|---|
Anti-NF-κB | Homodimer p50, heterodimer p50/p65 | Inhibitors of NF-κB |
Anti-TBP | TBP, TBP•TATA | Tool to study protein–protein interactions and inhibition |
Anti-HSF1 | HSF1 | Tool to understand transcriptional mechanisms and inhibitors |
Anti-RUNX1 | RHD-CBFβ, Runt | Inhibitors |
CBF, core-binding factor; NF-κB, nuclear factor-kappaB; RHD, runt homology domain; RUNX1, runt-related transcription factor 1; TBP, TATA-binding protein.