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(A) Mechanistic proposal for the radical-triggered conversion of AIR to HBI catalyzed by HBI synthase. (B) Homology model for HBI synthase. (C) X-ray structure of the ThiC active site. The [4Fe-4S] cluster, additional iron, SAM, AIR, and key active site residues are shown. SAM was generated by adding a methyl group in the S-configuration to SAH. The additional iron is also chelated to two conserved side chains (His270 and His334) in HBI synthase and His426 and His490 in ThiC.
