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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Jan 7;26(4):1305–1309. doi: 10.1016/j.bmcl.2016.01.012

Table 5.

Inhibition of antibiotic activity using PAO581 in the microdiffusion assay.

strain PAO581 alginate CF sputum
1c 0.61 0.89
1p 0.80 0.49
ciprofloxacin 0.97 −0.33
tobramycin 0.98 0.0

n = 0 (drag bioavailability not affected)

n = 0 < to 1 (drug bioavailability decreased)

n < 0 (drug bioavailability increased)