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Trial sequential analysis of 10 studies reporting the association between IL-10 -819C/T polymorphism and CAD. The required information size was calculated using α = 0.05 (two sided), β = 0.20 (power 80%), D2 = 8%, a relative risk reduction of 11% and an event proportion of 52.54% in the control arm. The blue cumulative Z-curve was constructed using a fixed-effects model. CAD = coronary artery disease.
