Table 1.
Comparison of sleep phenotypes among HD full-length and N-terminal insertion lines
| UAS-Htt128Q | Full length (M36) | N-term (F27B) | N-term (NtX) | N-term (M64) |
|---|---|---|---|---|
| Chromosome insertion | II | III | X | III |
| Total day sleep change | NS | NS | ↑ | ↑ |
| Average day bout | NS | ↑ | ↑ | ↑ |
| Day bout # | NS | NS | NS | ↑ |
| Average day activity | NS | ↑ | ↓ | ↓ |
| Total night sleep change | ↓ | ↓ | ↓ | ↓ |
| Average night bout | ↓ | ↓ | ↓ | ↓ |
| Night bout # | ↑ | ↑ | ↑ | ↑ |
| Average night activity | ↑ | ↑ | ↑ | ↑ |
| Rebound sleep after SD | ↓ | ↓ | Not tested | Not determined*** |
| Day bout # after SD | ↑ | ↑ | Not tested | Not determined*** |
| Average day bout after SD | ↓ | ↓ | Not tested | Not determined*** |
| Night bout # after SD | ↑ | ↑ | Not tested | Not determined*** |
| Average night bout after SD | ↓ | ↓ | Not tested | Not determined*** |
| Lethality of SD | 5–10% | 10–20% | Not tested | >60% |
SD, sleep deprivation (12 h).
NS, not significantly different from -elav controls.
Not determined***, insufficient n due to lethality of sleep deprivation.
Comparisons were made between flies expressing the specified HD transgene under the control of the elavG28-Gal4 driver and siblings lacking the Gal4 driver.