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. 2016 Jan 5;25(5):1031–1041. doi: 10.1093/hmg/ddv626

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Relationship between the level of mtDNA heteroplasmy in mothers and offspring for five pathogenic mtDNA mutations. Maternal and offspring heteroplasmy levels are displayed as a proportion. Red symbols= affected proband, green symbols= mother of the proband, blue= other relatives. Circles= meta-analysis data, triangles= new pedigree data measured at Centre 1, squares= new pedigree data measured at Centre 2. m.3243A>G corrected refers to heteroplasmy values after a correction for the known decline in heteroplasmy levels with age (14).