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. 2016 Feb 18;23(1):34–41. doi: 10.3747/co.23.2806

FIGURE 1.

FIGURE 1

The Notch1 signalling pathway. (A) The binding of Notch1 ligand (DSL) with the Notch1 receptor activates two subsequent protease cleavages. Afterward, intracellular Notch1 (ICN1) translocates into the nucleus where it interacts with other coactivators in a protein complex for the induction of Notch1 target genes. ADAM = A disintegrin and metalloproteinase; MAML = mastermind-like protein; MP = metal-loproteinase; CSL = CBF1/Su(H)/Lag-1 transcription factor complex. (B) The Notch1 signalling pathway promotes leukemia stem cell (LSC) activity by upregulation of IGF1R and c-Myc target genes and the indirect downregulation of protein kinase C–theta (PKCθ). RUNX3/1 = runt-related transcription factor 3/1.